D2388
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D2388
Aldrich
Dimethyl 3,3′-dithiopropionimidate dihydrochloride
powder
| Synonym: | Dimethyl 3,3′-dithio-bis(propionimidate) dihydrochloride, DTBP, Wang/Richards’ reagent |
| CAS Number: | 38285-78-8 |
| Linear Formula: | C8H16N2O2S2 · 2HCl |
| Molecular Weight: | 309.28 |
| MDL number: | MFCD00043245 |
| PubChem Substance ID: | 24893682 |
Description
| Application | A homobifunctional, cleavable cross-linking reagent. Typically, reacted with primary amines in the pH range 7.0-10.0 to form amidine bonds. |
| Caution | The reagant is readily hydrolyzed at neutral pH. Avoid use of reducing agents during coupling reactions. |
| Other Notes | Note that the amidine linkage preserves original primary amine positive charge. The disulfide linkage is cleavable by mild reduction. Incorporates an eight atom linker. |
Properties
| form | powder |
| solubility | H2O: 50 mg/mL |
| storage temp. | 2-8°C |
Safety
References
| reference | Ruoho, A., et al., A disulfide-bridge bifunctional imidoester as a reversible cross-linking reagent. Biochem. Biophys. Res. Commun. 63, 417-423, (1975) Abstract |
